Clinical Articles

Clinical Articles About the NeuroBlate™ System

Please note that some of these studies may involve findings that exceed the claims currently cleared by the FDA for the product. Monteris Medical is not intending to make performance claims about its product. The NeuroBlate device is a surgical tool and is not a treatment for any specific disease state or condition. The intent is to disseminate the scientific literature on these products. We encourage you to read these studies to understand the strengths and limitations of the data. For some claims, Monteris Medical is seeking to broaden the indications with the FDA in the future using data, such as these studies, to provide the substantiation. See for Full Prescribing Information. You can also download our full Clinical Publications Bibliography. If you have further questions about this collection of articles, please contact Monteris Clinical Affairs at (763) 253-4714.


Primary Research Articles

Publication Year Author Title
Cancer Medicine 2014 Mohammadi, Alireza M. MD; Hawasli, Ammar H. MD PhD et. al. The Role of Laser Interstitial Thermal Therapy in Enhancing Progression-Free Survival of Difficult-To-Access High-Grade Gliomas: A Multicenter Study
Epilepsia 2016 Kang JY, Wu C, Tracy J, Lorenzo M, et al. Laser Interstitial Thermal Therapy for Medically Intractable Mesial Temporal Lobe Epilepsy
Epilepsia 2015 Drane DL, Loring DW, Voets NL, et. al. Better Object Recognition and Naming Outcome with MRI-Guided Stereotactic Laser Amygdalohippocampotomy for Temporal Lobe Epilepsy
Epilepsy & Behavior 2015 Waseem H, Osborn K, Schoenberg MR, et al. Laser Ablation Therapy: An Alternative Treatment for Medically Resistant Mesial Temporal Lobe Epilepsy After Age 50
European Journal of Radiology 2006 Schwarzmaier HJ, Eickmeyer F, von Tempelhoff W, et al. MR-Guided Laser-Induced Interstitial Thermotherapy of Recurrent Glioblastoma Multiforme: Preliminary Results in 16 Patients.
Journal of Magnetic Resonance Imaging 2005 Schwarzmaier HJ, Eickmeyer F, von Tempelhoff W, et al. MR-Guided Laser Irradiation of Recurrent Glioblastomas
Journal of
2013 Torres-Reveron J, Tomasiewicz HC, Shetty A, et al. Stereotactic Laser Induced Thermotherapy (LITT): A Novel Treatment for Brain Lesions Regrowing After Radiosurgery
Journal of Neurosurgery 2016 Patel P, Patel NV, Danish SF Intracranial MR-Guided Laser-Induced Thermal Therapy: SingleCenter Experience With the Visualase Thermal Therapy System
Journal of Neurosurgery 2016 Pruitt R, Gamble A, Black K, et al. Complication Avoidance in Laser Interstitial Thermal Therapy: Lessons Learned
Journal of Neurosurgery 2013 Andrew E. Sloan, D, ManMeet S. Ahluwalia, MD, et. al. Link to Article Results of The NeuroBlate Systems First In Human Phase I Clinical Trial for Recurrent Glioblastoma
Journal of Neurosurgery: Pediatrics 2016 Tovar-Spinoza Z, Choi H Magnetic Resonance-Guided Laser Interstitial Thermal Therapy: Report of a Series of Pediatric Brain Tumors
Journal of
2011 Jethwa PR, Lee JH, Assina R, et. al. Treatment of a Supratentorial Primitive Neuroectodermal Tumor
Using Magnetic Resonance-Guided Laser-Induced Thermal Therapy
Lasers in Surgery and Medicine 2012 Carpentier A, Chauvet D, Reina V, et al. MR-Guided Laser-Induced Thermal Therapy (LITT) for Recurrent Glioblastomas.
Lasers in Surgery and Medicine 2011 Carpentier A, McNichols RJ, Stafford RJ, et al. Laser Thermal Therapy: Real-Time MRI-Guided and Computer-Controlled Procedures for Metastatic Brain Tumors
Neurosurgery 2015 McCracken JD, Willie JT, Fernald BA, et al. Magnetic Resonance Thermometry-Guided Stereotactic Laser Ablation of Cavernous Malformations in Drug-Resistant Epilepsy: Imaging and Clinical Results
Neurosurgery 2014 Willie JT, Laxpati NG, Drane DL, et al. Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy
Neurosurgery 2013 Hawasli AH, Bagade S, Shimony JS, et al. Magnetic resonance imaging-guided focused laser interstitial thermal therapy for intracranial lesions: single-institution series
Neurosurgery 2012 Jethwa PR, Barrese JC, Gowda A, et al. Magnetic Resonance Thermometry-Guided Laser-Induced Thermal Therapy for Intracranial Neoplasms: Initial Experience
Neurosurgery 2012 Hawasli, Ammar H. MD, PhD; Ray, Wilson Z. MD et. al. Technical Case Report: MRI Guided Focused Laser Interstitial Thermal Therapy for Subinsular Metastatic Adencarcinoma
Neurosurgery 2008 Carpentier A, McNichols RJ, Stafford RJ, et al. Real-Time Magnetic Resonance-Guided Laser Thermal Therapy for Focal Metastatic Brain Tumors
Photonics & Lasers in Medicine 2013 Missios, S., Schroeder, J., Barnett, G., et al. Prognostic factors of overall survival after laser interstitial thermal therapy in patients with glioblastoma
Photonics & Lasers in Medicine 2013 Schroeder, J., Missios, S., Barnett, G., et al. Laser interstitial thermal therapy as a novel treatment modality for brain tumors in the thalamus and basal ganglia
PLOS ONE 2016 Leuthardt EC, Duan C, Kim MJ, et al. Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain Barrier


Journal Year Author Title
and Functional
2016 Barnett GH, Voigt JD, Alhuwalia MS A Systematic Review and Meta-Analysis of Studies Examining the Use of Brain Laser Interstitial Thermal Therapy versus Craniotomy for the Treatment of High-Grade Tumors in or near Areas of Eloquence: An Examination of the Extent of Resection and Major Complication Rates Associated with Each Type of Surgery

Book Chapters

Journal/Publication Year Author Title
Neurooncology –
Newer Developments, Prof. Amit Agrawal
(Ed.), InTech, DOI:
2016 Sharma M, Silva D, Balasubramanian S, et. Al. Chapter Title: Laser Ablation in Neuro-Oncology

Review Articles

Journal/Publication Year Author Title
Expert Reviews in Neurotherapeutics 2016 Sharma M, Balasubramanian S, Silva D, et al. Laser Interstitial Thermal Therapy in the Management of Brain Metastasis and Radiation Necrosis After Radiosurgery: An Overview
Translational Pediatrics 2016 Karsy M, Guan J, Ducis K, Bollo RJ Emerging Surgical Therapies in the Treatment of Pediatric Epilepsy
Neurosurgical Focus 2015 Missios S, Bekelis K, and Barnett GH. Renaissance of Laser Interstitial Thermal Ablation
Expert Review of Medical Devices 2014 Mohammadi, AM and Schroeder, JL. Laser interstitial thermal therapy in treatment of brain tumors – the NeuroBlate System
Neurosurgical Focus 2014 Hawasli AH, Kim AH, Dunn GP, et al. Stereotactic Laser Ablation of High-Grade Gliomas
Oncology 2014 Rahmathulla G, Recinos PF, Kamian K, et al. MRI-Guided Laser Interstitial Thermal Therapy in Neuro-Oncology: A Review of Its Current Clinical Applications
Photonics & Lasers in Medicine 2014 Voigt, J. & Torchia, M. Laser interstitial thermal therapy with and without MRI guidance for treatment of brain neoplasms – A systematic review of the literature
Surgical Neurology International 2014 Wilson TA, Karajannis MA, and Harter DH. Glioblastoma multiforme: State of the art and future therapeutics
Journal of Neurosurgery 2013 Elder JB, Chiocca EA. Editorial: Glioblastoma multiforme and laser interstitial thermal therapy
Current Neurology and Neuroscience Reports 2011 Sherman JH, Hoes K, Marcus J, et al. Neurosurgery for Brain Tumors: Update on Recent Technical Advances

Economic Articles

Journal/Publication Year Author Title
Cost Effectiveness and Resource Allocation 2016 Voight J, Barnett G. The Value of Using a Brain Laser Interstitial Thermal Therapy (LITT) System in Patients with High Grade Gliomas Where Maximal Safe Resection May Not Be Feasible