Clinical Articles

Clinical Articles About the NeuroBlate™ System

Please note that some of these studies may involve findings that exceed the claims currently cleared by the FDA for the product. Monteris Medical is not intending to make performance claims about its product. The NeuroBlate device is a surgical tool and is not a treatment for any specific disease state or condition. The intent is to disseminate the scientific literature on these products. We encourage you to read these studies to understand the strengths and limitations of the data. For some claims, Monteris Medical is seeking to broaden the indications with the FDA in the future using data, such as these studies, to provide the substantiation. See for Full Prescribing Information. You can also download our full Clinical Publications Bibliography. If you have further questions about this collection of articles, please contact Monteris Clinical Affairs at (763) 253-4714.


Primary Research Articles

Publication Year Author Title
Cancer Medicine 2014 Mohammadi, Alireza M. MD; Hawasli, Ammar H. MD PhD et. al. The Role of Laser Interstitial Thermal Therapy in Enhancing Progression-Free Survival of Difficult-To-Access High-Grade Gliomas: A Multicenter Study
Childs Nervous System 2016 Tovar-Spinoza Z, Choi H MRI-guided laser interstitial thermal therapy for the treatment of low-grade gliomas in children: a case-series review, description of the current technologies and perspectives
Epilepsia 2017 Jermakowicz W, Kanner AM, Sur S, et al. Laser thermal ablation for mesiotemporal epilepsy: Analysis of ablation volumes and trajectories
Epilepsia 2016 Kang JY, Wu C, Tracy J, Lorenzo M, et al. Laser Interstitial Thermal Therapy for Medically Intractable Mesial Temporal Lobe Epilepsy
Epilepsia 2015 Drane DL, Loring DW, Voets NL, et. al. Better Object Recognition and Naming Outcome with MRI-Guided Stereotactic Laser Amygdalohippocampotomy for Temporal Lobe Epilepsy
Journal of Clinical Neuroscience 2016 Habboub G, Sharma M, Barnett GH, Mohammadi AM. A novel combination of two minimally invasive surgical techniques in the management of refractory radiation necrosis: Technical note
Journal of Neurosurgery 2016 Patel P, Patel NV, Danish SF Intracranial MR-Guided Laser-Induced Thermal Therapy: SingleCenter Experience With the Visualase Thermal Therapy System
Journal of Neurosurgery 2016 Pruitt R, Gamble A, Black K, et al. Complication Avoidance in Laser Interstitial Thermal Therapy: Lessons Learned
Journal of Neurosurgery 2013 Andrew E. Sloan, D, ManMeet S. Ahluwalia, MD, et. al. Link to Article Results of The NeuroBlate Systems First In Human Phase I Clinical Trial for Recurrent Glioblastoma
Journal of Neurosurgery: Pediatrics 2016 Tovar-Spinoza Z, Choi H Magnetic Resonance-Guided Laser Interstitial Thermal Therapy: Report of a Series of Pediatric Brain Tumors
Journal of
2011 Jethwa PR, Lee JH, Assina R, et. al. Treatment of a Supratentorial Primitive Neuroectodermal Tumor
Using Magnetic Resonance-Guided Laser-Induced Thermal Therapy
Neurosurgery 2017 Chaunzwa TL, Deng D, Leuthardt EC, Tatter SB, Mohammadi AM, Barnett GH, Chiang VL. Laser Thermal Ablation for Metastases Failing Radiosurgery: A Multicentered Retrospective Study
Neurosurgery 2016 Smith CJ, Myers CS, Chapple KM, Smith KA. Long-Term Follow-up of 25 Cases of Biopsy-Proven Radiation Necrosis or Post-Radiation Treatment Effect Treated With Magnetic Resonance-Guided Laser Interstitial Thermal Therapy
Neurosurgery 2013 Hawasli AH, Bagade S, Shimony JS, et al. Magnetic resonance imaging-guided focused laser interstitial thermal therapy for intracranial lesions: single-institution series
Neurosurgery 2012 Jethwa PR, Barrese JC, Gowda A, et al. Magnetic Resonance Thermometry-Guided Laser-Induced Thermal Therapy for Intracranial Neoplasms: Initial Experience
Neurosurgery 2012 Hawasli, Ammar H. MD, PhD; Ray, Wilson Z. MD et. al. Technical Case Report: MRI Guided Focused Laser Interstitial Thermal Therapy for Subinsular Metastatic Adencarcinoma
Neurosurgical Focus 2016 Thomas JG, Rao G, Kew Y, Prabhu SS. Laser interstitial thermal therapy for newly diagnosed and recurrent glioblastoma
Neurosurgical Focus 2016 Pisipati S, Smith KA, Shah K, Ebersole K, Chamoun RB, Camarata PJ. Intracerebral laser interstitial thermal therapy followed by tumor resection to minimize cerebral edema.
Neurosurgical Focus 2016 Wright J, Chugh J, Wright CH, Alonso F, Hdeib A, Gittleman H, Barnholtz-Sloan J, Sloan AE Laser interstitial thermal therapy followed by minimal-access transsulcal resection for the treatment of large and difficult to access brain tumors
Neurosurgical Focus 2016 Sharma M, Habboub G, Behbahani M, Silva D, Barnett GH, Mohammadi AM. Thermal injury to corticospinal tracts and postoperative motor deficits after laser interstitial thermal therapy
Neurosurgical Focus 2016 Dadey DY, Kamath AA, Smyth MD, Chicoine MR, Leuthardt EC, Kim AH. Utilizing personalized stereotactic frames for laser interstitial thermal ablation of posterior fossa and mesiotemporal brain lesions: a single-institution series
Neurosurgical Focus 2016 meir NJ, McInerney J, Zacharia BE The use of custom 3D printed stereotactic frames for laser interstitial thermal ablation: technical note
Neurosurgical Focus 2016 Dadey DY, Kamath AA, Leuthardt EC, Smyth MD Laser interstitial thermal therapy for subependymal giant cell astrocytoma: technical case report
Photonics & Lasers in Medicine 2014 Missios S, Schroeder JL, Barnett GH, et al. Prognostic Factors of Overall Survival After Laser Interstitial Thermal Therapy in Patients with Glioblastoma
Photonics & Lasers in Medicine 2014 Schroeder, J., Missios, S., Barnett, G., et al. Laser Interstitial Thermal Therapy as a Novel Treatment Modality for Brain Tumors in the Thalamus and Basal Ganglia
PLOS ONE 2016 Leuthardt EC, Duan C, Kim MJ, et al. Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain Barrier
Stereotactic and Functional Neurosurgery 2012 Rahmathulla G, Recinos PF, Valerio JE, Chao S, Barnett GH. Laser interstitial thermal therapy for focal cerebral radiation necrosis: a case report and literature review


Journal Year Author Title
Journal of Clinical Neuroscience 2016 Lagman C, Chung LK, Pelargos PE, Ung N, Bui TT, Lee SJ, Voth BL, Yang I. Laser neurosurgery: A systematic analysis of magnetic resonance-guided laser interstitial thermal therapies.
Neurosurgery 2016 Lee I, Kalkanis S, Hadjipanayis CG. Stereotactic Laser Interstitial Thermal Therapy for Recurrent High-Grade Gliomas
Neurosurgery 2016 Ivan ME, Mohammadi AM, De Deugd N, Reyes J, Rodriguez G, Shah A, Barnett GH, Komotar RJ. Laser Ablation of Newly Diagnosed Malignant Gliomas: a Meta-Analysis.
Stereotactic and Functional Neurosurgery 2016 Barnett GH, Voigt JD, Alhuwalia MS. A Systematic Review and Meta-Analysis of Studies Examining the Use of Brain Laser Interstitial Thermal Therapy versus Craniotomy for the Treatment of High-Grade Tumors in or near Areas of Eloquence: An Examination of the Extent of Resection and Major Complication Rates Associated with Each Type of Surgery

Book Chapters

Journal/Publication Year Author Title
Neurooncology –
Newer Developments, Prof. Amit Agrawal
(Ed.), InTech, DOI:
2016 Sharma M, Silva D, Balasubramanian S, et. Al. Chapter Title: Laser Ablation in Neuro-Oncology

Review Articles

Journal/Publication Year Author Title
Frontiers in Surgery 2016 LaRiviere MJ, Gross RE. Stereotactic Laser Ablation for Medically Intractable Epilepsy: The Next Generation of Minimally Invasive Epilepsy Surgery
Expert Reviews in Neurotherapeutics 2016 Sharma M, Balasubramanian S, Silva D, et al. Laser Interstitial Thermal Therapy in the Management of Brain Metastasis and Radiation Necrosis After Radiosurgery: An Overview
Translational Pediatrics 2016 Karsy M, Guan J, Ducis K, Bollo RJ Emerging Surgical Therapies in the Treatment of Pediatric Epilepsy
Neurosurgical Focus 2015 Missios S, Bekelis K, and Barnett GH. Renaissance of Laser Interstitial Thermal Ablation
Expert Review of Medical Devices 2014 Mohammadi, AM and Schroeder, JL. Laser interstitial thermal therapy in treatment of brain tumors – the NeuroBlate System
Photonics & Lasers in Medicine 2014 Voigt, J. & Torchia, M. Laser interstitial thermal therapy with and without MRI guidance for treatment of brain neoplasms – A systematic review of the literature
Journal of Neurosurgery 2013 Elder JB, Chiocca EA. Editorial: Glioblastoma multiforme and laser interstitial thermal therapy

Economic Articles

Journal/Publication Year Author Title
PharmacoEconomics 2016 Leuthardt EC, Voigt J, Kim AH, Sylvester P A Single-Center Cost Analysis of Treating Primary and Metastatic Brain Cancers with Either Brain Laser Interstitial Thermal Therapy (LITT) or Craniotomy
Cost Effectiveness and Resource Allocation 2016 Voight J, Barnett G. The Value of Using a Brain Laser Interstitial Thermal Therapy (LITT) System in Patients with High Grade Gliomas Where Maximal Safe Resection May Not Be Feasible